Highlighted Publications

Science Translational Medicine

Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction

Thavapalachandran, S., Grieve, S., Hume, R., Le, T., Raguram, K., Hudson, J., Pouliopoulos, J., Figtree, G., Dye, R., Barry, A., Brown, P., Lu, J., Coffey, S., Kesteven, S., Mills, R., Rashid, F., Taran, E., Kovoor, P., Thomas, L., Denniss, A., Kizana, E., Asli, N., Xaymarden, M., Feneley, M., Graham, R., Harvey, R., Chong, J. (2020)

Publication List

2024:

• Selvakumar, D, Clayton, ZE, Prowse, A, Dingwall, S, Kim, SK, Reyes, L, George, J, Shah, H, Chen, S, Leung, HHL, Hume, RD, Tjahjadi, L, Igoor, S, Skelton, RJP, Hing, A, Paterson, H, Foster, SL, Pearson, L, Wilkie, E, Marcus, AD, Jeyaprakash, P, Wu, Z, Chiu, HS, Ongtengco, CFJ, Mulay, O, Mcarthur, JR, Barry, T, Lu, J, Tran, V, Bennett, R, Kotake, Y, Campbell, T, Turnbull, S, Gupta, A, Nguyen, Q, Ni, G, Grieve, SM, Palpant, NJ, Pathan, F, Kizana, E, Kumar, S, Gray, PP & Chong, J. (2024), Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias. Nature Cardiovascular Research. Link

2023:

• Clayton Z., Santos M., Shah H., Lu J., Chen S., Shi H., Kanagalingam, S., Michael P., Wise S., Chong, J. (2023). Plasma polymerized nanoparticles are a safe platform for direct delivery of growth factor therapy to the injured heart. Frontiers in Bioengineering and Biotechnology. Link

• Hume, R, Deshmukh, T., Doan, T., Shim W., Kanagalingam, S., Tallapragada, V., Rashid, F., Marcuello M., Blessing D., Selvakumar, D., Raguram, K., Pathan F., Graham, D., Ounzain, S., Kizana, E., Harvey, R., Palpant N., & Chong, J. (2023). PDGF-AB Reduces Myofibroblast Differentiation Without Increasing Proliferation After Myocardial Infarction. JACC: Basic to Translational Science. Link

• Hume, R, Kanagalingam, S., Deshmukh, T., Chen, S., Mithieux, S., Rashid, F., Roohani, I., Lu, J., Doan, T., Graham, D., Clayton, Z., Slaughter, E., Kizana, E., Stempien-Otero, A., Brown, P., Thomas, L., Weiss, A., & Chong, J. (2023). Tropoelastin improves post-infarct cardiac function. Circulation Research. Link

• Selvakumar, D., Wilkie, E., Deshmukh, T., Ravindran, D., Kotake, Y., Lu, J., Barry, T., Tran, V., Paterson, H., Hing, A., Campbell, T., Kumar, S., Kizana, E., Chong, J. (2023).  Delivery of cardioactive therapeutics in a porcine myocardial infarction model. Journal of Visualized Experiments 2023. Link

2022:

• Hume, R, Deshmukh, T., Doan, T., Shim, WJ., Kanagalingam, S., Tallapragada, V., Rashid, F., Marcuello, M., Blessing, D., Selvakumar, D., Raguram, K., Pathan, F., Graham, D., Ounzain, S., Kizana, E., Harvey, R., Palpant, N., Chong, J. (2022). PDGF-AB reduces myofibroblast differentiation without increasing proliferation after myocardial infarction. JACC Basic to Translational Science. Link

• Selvakumar, D., Reyes, L., Chong, J. (2022). Cardiac cell therapy with pluripotent stem cell derived cardiomyocytes: What has been done and what remains to do. Current Cardiology Reports. Link

• Selvakumar, D., Deshmukh, T., Foster, S., Sanaei, N., Min, A., Grieve, S., Pathan, F., Chong, J. (2022). Comparative assessment of motion averaged free-breathing or breath-held cardiac magnetic resonance imaging protocols in a porcine myocardial infarction model. Scientific Reports. Link

2021:

• Thavapalachandran, S., Le, T., Romanazzo, S., Rashid, F., Ogawa, M., Kilian K., Brown, P., Pouliopoulos, J., Barry, A., Fahmy, P., Kelly, K., Kizana, E., Chong, J. (2021). Pluripotent stem cell-derived mesenchymal stromal cells improve cardiac function and vascularity after myocardial infarction. Cytotherapy. Link

• Rashid, F. , Clayton, Z.,Ogawa, M.,Perdomo, J., Kizana, E.,Chong, J. (2021). Platelet Derived Growth Factor A (Pdgf-a) gene transfer modulates scar composition and improves left ventricular function after myocardial infarction. International Journal of Cardiology. Link

• Zhang, J., Tomov, M., Chong, J., Menasche, P., Serpooshan, V. (2021). Bioengineering and biotechnology approaches in cardiovascular sciences. Frontiers in Bioengineering and Biotechnology. Accepted July 2021.

• Kalra, K., Eberhard, J., Farbehi, N., Chong, J., Xaymardan, M. (2021). Role of PDGF-A/B ligands in cardiac repair after myocardial infarction. Frontiers in Developmental Biology. Accepted July 2021.

• Deshmukh, T., Emerson, P., Geenty, P., Mahendran, S., Stefani, L., Hogg, M., Brown, P., Panicker, S., Chong, J., Altman, M., Gottlieb, D., & Thomas, L. (2021). The utility of strain imaging in the cardiac surveillance of bone marrow transplant patients. Heart (British Cardiac Society). Link

• Chilingaryan, Z.*, Deshmukh, T.*, Leung, H., Perdomo, J., Emerson, P., Kurup, R., Chong, B., Chong, J. (2021). Erythrocyte interaction with neutrophils extracellular traps in coronary artery thrombosis following myocardial infarction. Pathology. Accepted May 2021.

• Deshmukh, T., Kumar, S., & Chong, J. J. . (2021). Cardiac Inflammation After Myocardial Infarction and its Impact on Ventricular Arrhythmias. Heart, Lung & Circulation, 30(6), 783–785. Link

2020:

• Hume, R., Chong, J. (2020). The Cardiac Injury Immune Response as a Target for Regenerative and Cellular Therapies. Clinical Therapeutics, 42(10), 1923-1943. Link

• Ravindran, D., Kok, C., Farraha, M., Selvakumar, D., Clayton, Z., Kumar, S., Chong, J., Kizana, E. (2020). Gene and Cell Therapy for Cardiac Arrhythmias. Clinical Therapeutics, 42(10), 1911-1922. Link

• Chong, J., Thompson, P. (2020). Clarifying the Role of Stem Cells in Cardiac Clinical Therapeutics. Clinical Therapeutics, 42(10):1854-1856. Link

• Selvakumar, D., Clayton, Z., Chong, J (2020). Robust Cardiac Regeneration: Fulfilling the Promise of Cardiac Cell Therapy. Clinical Therapeutics, 42(10):1857-1879. Link

• White, S., Chong, J. (2020). Mesenchymal Stem Cells in Cardiac Repair: effects on Myocytes, Vasculature, and Fibroblasts. Clinical Therapeutics, 42(10):1880-1891. Link

• White, S., Chong, J. (2020). Growth factor therapy for cardiac repair: an overview of recent advances and future directions. Biophysical Reviews, 12(4), 805-815. Link

• Thavapalachandran, S., Grieve, S., Hume, R., Le, T., Raguram, K., Hudson, J., Pouliopoulos, J., Figtree, G., Dye, R., Barry, A., Coffey, S., Rashid, F., Kizana, E., Asli, N., Chong, J., et al (2020). Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction. Science Translational Medicine, 12(524), 1-11. Link

• Deshmukh, T., Emerson, P., Anderson, P., Kizana, E., O'Connell, P., Holmes-Walker, J., Chong, J. (2020). Cardiac Autonomic Neuropathy Is Not Reversed by Euglycemia Following Islet Transplantation. Transplantation, In Press. Link

• Farraha, M., Lu, J., Trivic, I., Barry, M., Chong, J., Kumar, S., Kizana, E. (2020). Development of a sheep model of atrioventricular block for the application of novel therapies. PloS One, 15(2), e0229092. Link

2019:

• Farraha, M., Barry, M., Lu, J., Pouliopoulos, J., Le, T., Igoor, S., Rao, R., Kok, C., Chong, J., Kizana, E. (2019). Analysis of recombinant adeno-associated viral vector shedding in sheep following intracoronary delivery. Gene Therapy. 26 (9) , 399-406. Link

• Chong, J., Prince, R., Thompson, P., Thavapalachandran, S., Ooi, E., Devine, A., Lim, E., Byrnes, E., Wong, G., Lim, W., Lewis, J. (2019). Association Between Plasma Neutrophil Gelatinase-Associated Lipocalin and Cardiac Disease Hospitalizations and Deaths in Older Women. Journal of the American Heart Association. 8 (1) , 1-13. Link

• Kott, K., Vernon, S., Hansen, T., Yu, C., Bubb, K., Coffey, S., Sullivan, D., Yang, J., O'Sullivan, J., Chow, C., Patel, S., Chong, J., Celermajer, D., Kritharides, L., Grieve, S., Figtree, G. (2019). Biobanking for discovery of novel cardiovascular biomarkers using imaging-quantified disease burden: protocol for the longitudinal, prospective, BioHEART-CT cohort study. BMJ Open. 9 (9) , 1-9. Link

• Le, T., Pickett, H., Yang, A., Ho, J., Thavapalachandran, S., Igoor, S., Yang, S., Farraha, M., Voges, H., Hudson, J., Dos Remedios, C., Bryan, T., Kizana, E., Chong, J. (2019). Enhanced cardiac repair by telomerase reverse transcriptase over-expression in human cardiac mesenchymal stromal cells. Scientific Reports. 9 (1) , 1-17. Link

• Perdomo, J., Leung, H., Ahmadi, Z., Yan, F., Chong, J., Passam, F., Chong, B. (2019). Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia. Nature Communications. 10 (1) , 1-14. Link

• Qian, P., Barry, M., Lu, J., Al Raisi, S., Mina, A., Ryan, J., Bandodkar, S., Alvarez, S., James, V., Ronquillo, J., Clayton, Z., Chong, J., Kovoor, P., Pouliopoulos, J., McEwan, A., Thiagalingam, A., Thomas, S., et al (2019). Transcatheter microwave ablation can deliver deep and circumferential perivascular nerve injury without significant arterial injury to provide effective renal denervation. Journal of Hypertension. 37 (10) , 2083-2092. Link

• Ke, B., Zeng, Y., Zhao, Z., Han, F., Liu, T., Wang, J., Khalique, A., Lu, W., Chong, J., Lan, F., et al (2019). Uric acid: a potent molecular contributor to pluripotent stem cell cardiac differentiation via mesoderm specification. Cell Death and Differentiation. 26 (5) , 826-842. Link

2018:

• Qian, P., Barry, M., Lu, J., Al Raisi, S., Mina, A., Ryan, J., Bandodkar, S., Alvarez, S., James, V., Ronquillo, J., Varikatt, W., Clayton, Z., Chong, J., Kovoor, P., Pouliopoulos, J., McEwan, A., Thiagalingam, A., Thomas, S. (2018). Development and Validation of a Novel Microwave Transcatheter Renal Denervation System and an Intraprocedural Physiological End Point for Renal Sympathetic Denervation. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting. 27 , S43-S44. Link

• Farraha, M., Kumar, S., Chong, J., Cho, H., Kizana, E. (2018). Gene Therapy Approaches to Biological Pacemakers. Journal of Cardiovascular Development and Disease. 5 (4) , 1-17. Link

• Le, T., Pickett, H., Dos Remedios, C., Barbaro, P., Kizana, E., Chong, J. (2018). Platelet Derived Growth Factor Receptor-Alpha expressing cardiac progenitor cells can be derived from previously cryopreserved human heart samples. Stem Cells and Development. 27 (3) , 1-15. Link

• Qian, P., Barry, M., Lu, J., Mina, A., Ryan, J., Bandodkar, S., Alvarez, S., James, V., Ronquillo, J., Varikatt, W., Clayton, Z., Chong, J., Al Raisi, S., Kovoor, P., Pouliopoulos, J., McEwan, A., Thiagalingam, A., Thomas, S. (2018). TRANSCATHETER MICROWAVE ABLATION CAN PRODUCE DEEP CIRCUMFERENTIAL PERIVASCULAR ABLATION AND EFFECTIVE RENAL DENERVATION WITHOUT SIGNIFICANT ARTERIAL INJURY. Meeting of the American College of Cardiology 2018 (ACC.18). 71, Issue 11, Supplement , A1229. Link

• Le, T., Ogawa, M., Kizana, E., Gunton, J., Chong, J. (2018). Vitamin D Improves Cardiac Function After Myocardial Infarction Through Modulation of Resident Cardiac Progenitor Cells. Heart, Lung and Circulation. 27 (8) , 967-975. Link

2017:

• Le, T., Thavapalachandran, S., Kizana, E., Chong, J. (2017). New Developments in Cardiac Regeneration. Heart, Lung and Circulation. 26 (4) , 316-322. Link

2016:

• Le, T., Chong, J. (2016). Cardiac progenitor cells for heart repair. Cell Death Discovery. 2 , 1-4. Link

• Zheng, S., Chong, J., Chong, B. (2016). Pharmacodynamics, pharmacokinetics and clinical efficacy of apixaban in the treatment of thrombosis. Expert Opinion on Drug Metabolism and Toxicology. 12 (5) , 575-580. Link

• Farraha, M., Chong, J., Kizana, E. (2016). Therapeutic Prospects of Gene Therapy for Atrial Fibrillation. Heart, Lung and Circulation. 25 (8) , 808-813. Link

2015:

• Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews. 7 (1) , 127-139. Link

• Fernandes, S., Chong, J., Paige, S., Iwata, M., Torok-Storb, B., Keller, G., Reinecke, H., Murry, C. (2015). Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair. Stem cell reports. 5 (5) , 753-762. Link

• Ding, D., Chong, J., Jalaludin, B., Comino, E., Bauman, A. (2015). Risk factors of incident type 2-diabetes mellitus over a 3-year follow-up: Results from a large Australian sample. Diabetes Research and Clinical Practice. 108 (2) , 306-315. Link

2014:

• Chong, J., Murry, C. (2014). Cardiac regeneration using pluripotent stem cells-Progression to large animal models. Stem Cell Research. 13 (3) , 654-665. Link

• Chong, J., Forte, E., Harvey, R. (2014). Developmental origins and lineage descendants of endogenous adult cardiac progenitor cells. Stem Cell Research. 13 (3) , 592-614. Link

• Al Raisi, S., Pouliopoulos, J., Barry, M., Swinnen, J., Thiagalingam, A., Thomas, S., Sivagangabalan, G., Chow, C., Chong, J., Kizana, E., Kovoor, P. (2014). Evaluation of lesion and thermodynamic characteristics of Symplicity and EnligHTN renal denervation systems in a phantom renal artery model. EuroIntervention. 10 (2) , 277-284. Link

• Chong, J., Yang, X., Don, C., Minami, E., Liu, Y., Weyers, J., Mahoney, W., Van Biber, B., Cook, S., et al, V. (2014). Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature. 510 (7504) , 273-277. Link

• Murry, C., Chong, J., Laflamme, M. (2014). Letter by Murry et al Regarding Article, “Embryonic Stem Cell–Derived Cardiac Myocytes Are Not Ready for Human Trials”. Circulation Research. 115 (10) , e28-e29. Link

• Matar, A., Chong, J. (2014). Stem cell therapy for cardiac dysfunction. SpringerPlus. 3 (1) , 1-14. Link

2013:

• Chong, J., Chong, B. (2013). HIT: nucleic acid masquerading as heparin. Blood. 122 (2) , 156-158. Link

• Chong, J., Reinecke, H., Iwata, M., Torok-Storb, B., Stempien-Otero, A., Murry, C. (2013). Progenitor Cells Identified by PDGFR-Alpha Expression in the Developing and Diseased Human Heart. Stem Cells and Development. 22 (13) , 1932-1943. Link

2012:

• Chong, J. (2012). Cell therapy for left ventricular dysfunction: an overview for cardiac clinicians. Heart, Lung and Circulation. 21 (9) , 532-542. Link

2011:

• Chong, J., Chandrakanthan, V., Xaymardan, M., Asli, N., Li, J., Ahmed, I., Heffernan, C., Menon, M., Scarlett, C., Rashidianfar, A., Zoellner, H., et al (2011). Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin. Cell Stem Cell. 9 (6) , 527-540. Link

2010:

• Chong, B., Chong, J. (2010). IVIg immune inhibitory activity: APC is key. Blood. 115 (9) , 1663-1164. Link

2008:

• Chong, J., Ganesan, A., Eipper, V., Kovoor, P. (2008). Comparison of left ventricular ejection fraction and inducible ventricular tachycardia in ST-elevation myocardial infarction treated by primary angioplasty versus thrombolysis. The American Journal of Cardiology. 101 (2) , 153-157. Link

• Chong, J., Chard, R., McKay, T., Thomas, L. (2008). Two-dimensional and three-dimensional transthoracic echocardiography in surgical planning for right atrial metastatic melanoma.. European Journal of Echocardiography. 9 (2) , 286-288. Link